Statins and neuroprotection
نویسندگان
چکیده
منابع مشابه
Statins: mechanisms of neuroprotection.
Clinical trials report that the class of drugs known as statins may be neuroprotective in Alzheimer's and Parkinson's disease, and further trials are currently underway to test whether these drugs are also beneficial in multiple sclerosis and acute stroke treatment. Since statins are well tolerated and have relatively few side effects, they may be considered as viable drugs to ameliorate neurod...
متن کاملThe dynamics of statins: from event prevention to neuroprotection.
Working on new antibiotic candidates, Akira Endo found in 1976 that statins could strongly inhibit HMG-CoA reductase.1 It turned out that his discovery was the most important advance in cardiovascular prevention since aspirin and blood pressure–lowering. Contradicting most epidemiological studies which failed to find a link between cholesterol levels and stroke,2 statins strongly reduce stroke ...
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Statins are most effective pharmacologically agents to decrease total plasma cholesterol level by competitive inhibition of HMG-Co A reductase. Apart from the well-known LDL and cholesterol lowering effect, statins have been postulated to exert other beneficial effects also called pleotropic or non-lipid effects. Better understanding of various pleotropic effects of statins has prompted a new s...
متن کاملStatins and Pulmonary Hypertension in Chronic Obstructive Lung Disease
Chronic obstructive lung disease (COPD) is a chronic multisystem disease with a considerable burden. One of its most common complications is pulmonary artery hypertension (PAH). It has been demonstrated that the development of PAH is correlated with decreased quality of life and survival. Different medications have been proposed for the treatment of PAH, among which one can name statins. Howeve...
متن کاملmGluR5, CB1 and neuroprotection
The metabotropic glutamate receptor 5 (mGluR5) is a Gαq/11-coupled receptor, mainly found at the postsynaptic site. mGluR5 stimulation leads to the activation of phospholipase Cβ1 (PLCβ), promoting diacylglicerol (DAG) and inositol 1,4,5-trisphosphate (IP3) formation, which leads to the release of Ca2+ from the intracellular stores and the activation of protein kinases, including protein kinase...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2010
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2009.05359.x